Simultaneous recording of mechanical and intracellular electrical activity in human urinary bladder smooth muscle
نویسندگان
چکیده
منابع مشابه
Simultaneous recording of mechanical and intracellular electrical activity in human urinary bladder smooth muscle.
OBJECTIVE To elucidate the role of the membrane potential in human detrusor smooth muscle contraction, by simultaneously recording mechanical and intracellular electrical activity in muscle strips. Materials and methods The agonists acetylcholine and carbachol were applied to induce a contraction on muscarinic receptor stimulation; to block the response, atropine was added to the bath. The Ca2+...
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INTRODUCTION The primary key to pharmacotherapy of bladder instability is in the excitation-contraction coupling of detrusor smooth muscle cells. To study this process, simultaneous recordings of mechanical and electrical activity are required. However, recording of mechanical activity induces movement, which may affect the quality of intracellular recordings. MATERIALS AND METHODS We therefo...
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ژورنال
عنوان ژورنال: BJU International
سال: 2007
ISSN: 1464-4096,1464-410X
DOI: 10.1046/j.1464-410x.2000.00707.x